The Billboard Hot 100 Chart is published weekly by Billboard Magazine and is the industry standard for determining the most popular songs in the United States for a given week.
Below are the singles that were number one every week in 2010; such as "TiK ToK" by Ke$ha.
| Date | Song | Artist | |
| 2010-03-13 | Imma Be | Black Eyed Peas |
|
| 2010-03-06 | Imma Be | Black Eyed Peas |
|
| 2010-02-27 | TiK ToK | Kesha |
|
| 2010-02-20 | TiK ToK | Kesha |
|
| 2010-02-13 | TiK ToK | Kesha |
|
| 2010-02-06 | TiK ToK | Kesha |
|
| 2010-01-30 | TiK ToK | Kesha |
|
| 2010-01-23 | TiK ToK | Kesha |
|
| 2010-01-16 | TiK ToK | Kesha |
|
| 2010-01-09 | TiK ToK | Kesha |
|
| 2010-01-02 | TiK ToK | Kesha |
|